Small secreted proteins play an important role in plant development, as well as in reactions to changes in the environment. Our survey of the existing literature for the pathogenesis-related (PR) 1-like and Clavata3/Endosperm Surrounding Region (CLE) families showed a lack of details on their localization, trafficking, and exocytosis. Therefore, in order to uncover the modes of their secretion, we tested the hypothesis that a direct link between the secreted cargoes and the secretion regulators such as Rab GTPases, SNAREs, and exocyst subunits could be established using in silico co-expression and clustering approaches.